Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits   总被引：9，自引：0，他引：9  

Zhang M  Ma YF  Gan JX  Jiang GY  Xu SX  Tao XL  Hong A  Li JK 《Journal of Zhejiang University. Science. B》2005,6(7):637-643

The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities.  相似文献   

一种基于GPS/INS的导弹制导控制系统     

朱明星 《安徽科技学院学报》2008,22(3):17-19

导弹要准确的击中目标,制导技术是关键的环节。目前GPS技术的发展和应用,推动了导弹采用GPS/INS组合制导技术的发展。本文设计了采用GPS/INS组合制导技术的导弹制导控制系统,对GPS/INS组合制导技术进行了研究,并对其中采用的卡尔曼滤波算法进行了详细的介绍。  相似文献   

A family of quasi-cubic blended splines and applications   总被引：4，自引：0，他引：4  

SU Ben-yue TAN Jie-qing 《浙江大学学报(A卷英文版)》2006,7(9):1550-1560

INTRODUCTION Bézier curves and uniform B-spline curves are powerful tools for constructing free form curves and surfaces (FFC/FFS). But they cannot represent the arcs, hyperbola, sphere, cylinders and other transcendental curves and surfaces exactly. In order to avoid the in- conveniences, many bases are presented in other new spaces (Zhang, 1996; Pe?a, 1997; Walz, 1997; Sánchez-Reyes, 1998; Mainar et al., 2001). Note that, these existing methods can deal with both polynomial curve…  相似文献   

Swarm intelligence for mixed-variable design optimization     

郭创新  胡家声  叶彬  曹一家 《浙江大学学报(A卷英文版)》2004,5(7):851-860

Many engineering optimization problems frequently encounter continuous variables and discrete variables which adds considerably to the solution complexity.Very few of the existing methods can yield a globally optimal solution when the objective functions are non-convex and non-differentiable.This paper presents a hybrid swarm intelligence approach(HSIA)for solving these nonlinear optimization problems which contain integer,discrete,zero-one and continuous variables.HSIA provides an improvement in global search reliability in a mixed-variable space and converges steadily to a good solution.An approach to handle various kinds of variables and constraints is discussed.Comparison testing of several examples of mixed-variable optimization problems in the literature showed that the proposed approach is superior to current methods for finding the best solution,in terms of both solution quality and algorithm robustness.  相似文献   

大学校长全球峰会     

贺长中 《世界教育信息》2006,(5):12-13

为了响应联合国秘书长安南提出的“高等院校应该更多地参与国际公共政策和事务”倡议,纽约地区5所高校发起成立了大学校长全球峰会。首届峰会于2005年1月18日至19日在哥伦比亚大学举行,全球著名研究型大学的40多位校长和学者参加了会议,并于6月27日发表了《学术自由宣言》,倡议全球大学校长联合签名,共同创建自己认同的学术自由氛围和环境。  相似文献   

抢修车辆GPS卫星定位系统在福州电业局的应用     

郑旭涛 《福建工程学院学报》2003,1(2):79-81

对原有和现在的电力故障抢修状况进行对比分析，详细介绍了抢修车辆GPS卫星定位系统的硬件、应用软件和体系结构，及其建设成果。通过抢修车辆CPS卫星定位系统的建设，不仅加强了抢修车辆的管理。提高了抢修效率，而且引发了管理模式上的变化，大大提高了客户满意率。  相似文献   

Application of stochastic method to optimum design of energy-efficient induction motors with a target of LCC     

方攸同  范承志  叶云岳  陈永校 《Journal of Zhejiang University. Science. B》2003,(3)

INTRODUCTIONMostcountrieshaveimplementednewpoli ciesontheenergysavingandenvironmentpro tection.AmericanPresidentBushsigned“TheComprehensiveNationalEnergyPolicyAct”in1992statingthatnogeneral purpose ,three phaseinductionmotorswillbeallowedintoUnit edStat…  相似文献   

从供应链管理看企业发展的方向     

袁柳 《中国教育科研与探索》2006,(1):10-11

本文主要论述了供应链管理的含义，怎样通过合理的供应链管理减少交易成本，经济全球化给供应链带来的新的机遇和发展。未来供应链管理的发展趋势。  相似文献   

中国城市蔓延对绿色全要素生产率的影响   总被引：1，自引：0，他引：1  

邵汉华  夏海波 《资源科学》2020,42(4):790-800

提高城市发展质量是现阶段经济高质量发展的应有之义,中国城镇化进程中的城市蔓延已成为影响城市高质量发展的重要因素。本文利用2004—2017年中国285个地级及其以上城市面板数据,实证考察了城市蔓延与绿色全要素生产率之间异质性关系。研究发现：①城市适度蔓延对绿色全要素生产率起显著提升作用,蔓延过度则呈现抑制效应或者影响不明显;②就人口集聚的区域差异而言,城市蔓延对东部地区促进作用突出,而对中西部地区更多表现出抑制效应;③此外,随着经济超过最优集聚区间,两者之间的反方向关联变为同向关系,进一步发现,两者之间显著存在基于制造业集聚的“倒U型”门槛效应,而在服务业集聚程度较高的城市,城市蔓延的促进效应并不显著。本文深化了对城市蔓延影响城市绿色发展基本规律的认识和理解,为城市高质量发展的“顶层设计”提供了有益的参考,对中国正在推进的以中心城市引领城市群和新型城镇化战略也有着启示意义。  相似文献   

PPP在农业科技创新中的应用——企业“走出去”视角     

张斌  李海燕 《科技管理研究》2017,(16)

从企业"走出去"的视角,分析在农业科技创新中应用PPP的合理性,并重点探讨PPP在农业科技创新中的应用方式,包括应用条件、步骤、合作结构和风险等。  相似文献